O-Acyl Analogue of Dihydroxybutylphosphonate

September 06, 2016


In the previous years of studying bacteria, research had been employed to study various forms of antibiotics to prevent bacterial growth within the body. Extensive studies([4], [5], [13]) of the lipid membrane have been carried out to determine a way to penetrate their cells. Knowing which specific compound in the membrane is highly vital for lipid metabolism. It was deduced that one of the main compounds for bacterial lipid metabolism was sn-glycerol-3-phosphate (G3P) i.e. a precursor for the synthesis of phospholipids. The first antibiotic to be produced was 3,4- Dihydroxybutylphosphonate (3,4-DHBP)[13] which is the analogue inhibitor of 3GP. Due 3,4-DHBP containing hydroxyl groups, the compound is fairly soluble, hence this project was about producing an analogue of 3,4-DHBP that was more insoluble in its target. The objective for this project was to produce an O-acyl analogue of 3,4-DHBP, therefore by creating an O-acyl analogue, the extra added alkyl chains would allow the compound to less soluble.

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